IMPROVED MILBOND-TX ®
“SAFETY STUDIES WITH BROILERS“
BODY WEIGHT, FEED CONSUMPTION, FEED CONVERSION & EXCRETA MOISTURE
Improved Milbond-TX ® (IMTX) has been supplemented to poultry diets successfully since 1992 when it was first introduced to the animal feed industry by Milwhite, Inc. The recommended concentration of IMTX in feed is 0.25% (2.5 g/kg diet) and no safety issues, with respect to animal performance, have ever been documented when fed at this concentration. IMTX is an inert montmorillonite clay-based adsorbent originating from natural clay deposits mined directly from the earth. Even though in 1999 Dr. David Ledoux, at the University of Missouri (USA), reported that IMTX was safe when used at higher than recommended dietary concentration in broiler diets, Milwhite Inc. decided in 2006 to initiate studies in which specifically designed experiments were conducted by Dr. Richard Miles at the University of Florida (USA), that would ascertain the safety of IMTX in poultry diets when used at its recommended concentration and up to eight times that concentration. The goal of Milwhite, Inc. in having these studies conducted was to provide clients in the poultry and feed industry with evidence, gained by data collected in well-designed experiments, that if a feed mixing error occurred and IMTX was added to a diet at higher than its recommended concentration it would be completely safe and birds would perform normally. The studies demonstrating the safety of IMTX when fed at high dietary concentrations is the topic of this and other issues of “Milwhite’s Journal’ which will be published in the upcoming months.
In experiment 1, conducted at the University of Florida (Miles and Henry, 2007), broiler diets were formulated to be isocaloric and isonitrogenous and contained IMTX at concentrations of 0, 0.25, 0.50, 1.50 or 2.0 %. In the second experiment, in order to mimic a feed mixing error, these investigators decided to add IMTX directly to the finished feed (by weight) at concentrations of 0, 1.0 or 2.0 %. In both experiments, in order to eliminate extremes in initial pen body weights, five Ross X Ross male broiler chicks were selected by weight from a larger group and allocated randomly to pens in Petersime battery brooders in an environmentally controlled room with constant lighting. Dietary treatments were fed to 16 replicate pens each containing five chicks. All birds were offered diets and water ad-libitum throughout the entire 21-day experimental period. During the last 7 days of each experiment, excreta were collected separately for 48 hours in aluminum pans placed directly under each pen of birds. Following collection, each excreta sample was homogenized by hand for 2 minutes in a 2 L beaker using a spoon. Three sub-samples of approximately 2 grams each were used for moisture determination.
At all dietary concentrations of IMTX body weight of chicks at the end of each 7 days was similar to the control group of birds fed diets containing no supplemental IMTX. Feed consumption and feed conversion followed the same trend in both experiments with no significant differences observed among the dietary treatments. Excreta moisture was not affected in a negative manner (higher moisture content) at any dietary concentration of IMTX. In both experiments, the survivability of chicks was above 98%. Data collected in these two experiments, specifically designed to study the safety of IMTX when supplemented at higher than the recommended concentration, confirmed the fact, that IMTX is indeed safe to add to broiler diets at concentrations up to 2.0%, which is eight times the recommended amount to be used in a diet.
In the previously mentioned safety study which was conducted at the University of Missouri by Dr. Ledoux, these researchers (Ledoux et al. , 1999) fed a diet containing 1.0% IMTX to broilers and no detrimental response in bird performance was reported. It was reported in their publication that IMTX was totally effective in removing the toxic effects in broilers from feeding 4 mg/kg of Aflatoxin B1 and no detrimental effects in broiler performance resulted from supplementing IMTX to the diet at a concentration of 1.0% which is four times the recommended amount of 0.25%.
The information presented in this issue of MIL WHITE’S Journal was compiled by Dr. Orlando Osuna, Director of Health Science at Mi/white, Inc. and Dr. Richard Miles, Professor Emeritus, University of Florida, Gainesville, FL, USA.
Miles, RD. and P.R. Henry. 2007. Safety of Improved Milbond-TX® when fed in broiler diets at greater than recommended levels. Animal Feed Science and Technology. 138:309-317.
Ledoux, D.R., G.E. Rottinghaus, A.J. Bermudez and M. Alonso-Debolt. 1999. Efficacy of a hydrated sodium calcium aluminosilicate to ameliorate the toxic effects of aflatoxin in broiler chicks. Poultry Science. 78:204-210.
For additional information contact Dr. Orlando Osuna at 956-547-1970.